Tying Up the Fast Facts

Tying-up is also known as exertional rhabdomyolysis, azoturia, set fast, Monday morning disease, or paralytic myoglobinuria.

Affected horses are stiff, sweaty, reluctant to move, and often appear anxious.

Tying-up can be caused by a number of underlying conditions, including electrolyte, vitamin, and mineral imbalances; changes in exercise; abnormal muscle contraction; or genetic mutations causing an accumulation of glycogen in muscles. In many cases, the cause of tying-up is never established.

Diagnosis is based on clinical signs and markedly elevated muscle enzyme levels. Additional diagnostic tests might be recommended by a vet.

Preventative measures can be instituted to minimize recurrence of tying-up. These include dietary, training, and management strategies and possibly the use of pharmaceutical drugs (on the advice of a veterinarian).

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